The Greek Orthodox Ladies Philoptochos Society, Inc. is the philanthropic arm of the Greek Orthodox Archdiocese of America. Established in November 1931 by the late Ecumenical Patriarch Athenagoras I, it has been providing philanthropic aid for over 90 years through a variety of programs in the United States and around the world. Its mission is to assist the poor, destitute, hungry, aged, sick, unemployed, orphaned, imprisoned, widowed, those with disabilities, and victims of disasters. The society has 26,000 members and nearly 450 active chapters nationwide, and in 2023, it distributed $1.8 million in philanthropic aid.

Since the late 1950s, the society has placed increased emphasis on implementing programs to benefit the Greek Orthodox community, including support for Church institutions, the philanthropies of the Ecumenical Patriarchate, and assistance to Greek and Greek Orthodox families. It has also addressed various social and moral issues through committees focusing on topics such as child abuse prevention, domestic violence, homelessness, pornography, drug and alcohol abuse, and aging.

In 1987, the National Philoptochos office employed a professional social worker to assist the Greek Orthodox community in the United States, as well as Greek and Cypriot nationals. The Department of Social Services, a vital element of the organization, aims to improve the quality of life of those in need while maintaining their dignity and self-respect. The department provides confidential and professional services, outreach, education, information, support, intervention, motivation, advocacy, financial assistance, and referrals to local and broader resources.